OK Manu, here is a little update :
I reinstalled the game, launched, OK
I added again all my mods and profiles, launched, OK
I changed my sound and control settings, OK
I changed my resolution, launched, OK
I tried to enable FSAA : CRASH
I putted all the graphic settings at max with FSAA disabled : OK
So the problem is the FSAA. Do you know why ?
But now I can play, yihaaaa !!!!